Welcome to LookChem.com Sign In|Join Free

CAS

  • or

133031-38-6

Post Buying Request

133031-38-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

133031-38-6 Usage

Description

(2E)-1-(4-chlorophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one is a chalcone compound with the molecular formula C15H9Cl3O. It is a yellow solid that is insoluble in water but soluble in organic solvents. Chalcones are natural phenolic compounds found in many plants and have been studied for their potential biological activities, including antioxidant, anti-inflammatory, and anticancer properties.

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-chlorophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one is used as a pharmaceutical compound for its potential biological activities. Its antioxidant, anti-inflammatory, and anticancer properties make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Chemical Research:
(2E)-1-(4-chlorophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one is used as a research compound in chemical studies. Its unique properties and potential applications in various fields make it an interesting subject for further investigation and experimentation.
Note: The specific properties and uses of (2E)-1-(4-chlorophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one may vary depending on further research and testing.

Check Digit Verification of cas no

The CAS Registry Mumber 133031-38-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,3 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133031-38:
(8*1)+(7*3)+(6*3)+(5*0)+(4*3)+(3*1)+(2*3)+(1*8)=76
76 % 10 = 6
So 133031-38-6 is a valid CAS Registry Number.

133031-38-6Relevant articles and documents

Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII

Ceruso, Mariangela,Gratteri, Paola,Hargunani, Priya,Kazaks, Andris,Leitans, Janis,Nocentini, Alessio,Supuran, Claudiu T.,Tadge, Nikhil,Tars, Kaspars,Toraskar, Mrunmayee P.

, (2020/04/27)

A series of new 3-phenyl-5-aryl-N-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives was designed here, synthesized, and studied for carbonic anhydrase (CAs, EC 4.2.1.1) inhibitory activity against the human (h) isozymes I, II, and VII (cytosolic, off-target isoforms), and IX and XII (anticancer drug targets). Generally, CA I was not effectively inhibited, whereas effective inhibitors were identified against both CAs II (KIs in the range of 5.2-233 nM) and VII (KIs in the range of 2.3-350 nM). Nonetheless, CAs IX and XII were the most susceptible isoforms to this class of inhibitors. In particular, compounds bearing an unsubstituted phenyl ring at the pyrazoline 3 position showed 1.3-1.5 nM KIs against CA IX. In contrast, a subset of derivatives having a 4-halo-phenyl at the same position of the aromatic scaffold even reached subnanomolar KIs against CA XII (0.62-0.99 nM). Docking studies with CA IX and XII were used to shed light on the derivative binding mode driving the preferential inhibition of the tumor-associated CAs. The identified potent and selective CA IX/XII inhibitors are of interest as leads for the development of new anticancer strategies.

Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease

-

, (2011/02/23)

Methods are provided for treating chronic obstructive pulmonary diseases such as emphysema using compounds that activate the signaling pathways of hepatocyte growth factor.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 133031-38-6