133046-47-6

Basic information

• Product Name: [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol
• Synonyms: [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol;4-(Hydroxymethyl)-2-(trifluoromethyl)-1,3-thiazole
• CAS NO: 133046-47-6
• Molecular Formula: C₅H₄F₃NOS
• Molecular Weight: 183.1515696
• Mol File: 133046-47-6.mol

Chemical Properties

• Boiling Point: 176.8°C at 760 mmHg
• Flash Point: 60.7°C
• Appearance: /
• Density: 1.533g/cm³
• Vapor Pressure: 0.709mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol(133046-47-6)
• EPA Substance Registry System: [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol(133046-47-6)

Safety Data

• Hazardous Substances Data: 133046-47-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol is used as a key intermediate in the synthesis of pharmaceutical compounds due to its unique structural features. The trifluoromethyl group and the heterocyclic thiazole ring can contribute to the development of new drugs with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Agrochemical Industry:
In the agrochemical field, [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol is utilized as a building block for the creation of novel agrochemicals. Its structural attributes, including the trifluoromethyl group and the thiazole ring, can be leveraged to design pesticides or herbicides with increased effectiveness and selectivity, potentially leading to more sustainable agricultural practices.
Used in Organic Chemistry Research:
[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol serves as a valuable compound in organic chemistry research. Its unique structure allows chemists to explore various synthetic routes and reactions, leading to the discovery of new chemical entities and understanding of reaction mechanisms. This can contribute to the advancement of organic synthesis techniques and the development of new methodologies.

InChI:InChI=1/C5H4F3NOS/c6-5(7,8)4-9-3(1-10)2-11-4/h2,10H,1H2

Upstream product

• 133046-46-5 Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate 

Downstream Products

• 135207-07-7 4-(chloromethyl)-2-(trifluoromethyl)thiazole 
• 852854-38-7 4-(bromomethyl)-2-(trifluoromethyl)thiazole 

Relevant articles and documents

PAR4 AGONIST PEPTIDES

The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I) which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VRl, also known as TRPVl).

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).