133053-63-1

Upstream product

• 103589-71-5 3-Iodo-1,5-dimethylpyrazole-4-carbonamide 
• 13146-23-1 copper(I) phenylacetylenide 
• 133053-65-3 1,5-Dimethyl-3-phenylethynyl-1H-pyrazole-4-carboxylic acid amide 
• 79229-70-2 1,5-dimethyl-3-phenylethynylpyrazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A new route to pyrazolo[3,4-c] and [4,3-c]pyridinones via heterocyclization of vic-substituted hydroxamic acids of acetylenylpyrazoles

We report in this paper the synthesis of 6-substituted pyrazolo[4,3-c] pyridin-4-ones, 6-substituted 5-hydroxypyrazolo[4,3-c]pyridin-6-ones, 5-substituted pyrazolo[3,4-c]pyridin-7-ones and 5-substituted 6-hydroxypyrazolo[3,4-c]pyridin-7-ones by heterocyclization of vic-acetylenylpyrazol-hydroxamic acids under the influence of copper(I) salt in dimethylformamide or with organic bases in butanol or methanol. Graphical Abstract

CYCLIZATION OF VICINAL ACETYLENIC DERIVATIVES OF PYRAZOLECARBONAMIDES AND BENZAMIDES

Vicinal acetylenic derivatives of pyrazolecarbonamides and benzamides cyclize in alcoholic solution in the presence of KOH with closure of the six- or five-membered lactam ring.The formation of γ-lactam (from o-phenylethynylbenzamide) has been noted for t