133053-71-1

Basic information

• Product Name: N-(2-methyl-3-nitro-phenyl)-acetimidic acid ethyl ester
• Synonyms: N-(2-methyl-3-nitro-phenyl)-acetimidic acid ethyl ester
• CAS NO: 133053-71-1
• Molecular Weight: 222.244
• Mol File: 133053-71-1.mol

Chemical Properties

• CAS DataBase Reference: N-(2-methyl-3-nitro-phenyl)-acetimidic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methyl-3-nitro-phenyl)-acetimidic acid ethyl ester(133053-71-1)
• EPA Substance Registry System: N-(2-methyl-3-nitro-phenyl)-acetimidic acid ethyl ester(133053-71-1)

Safety Data

• Hazardous Substances Data: 133053-71-1(Hazardous Substances Data)

Upstream product

• 603-83-8 3-nitro-o-tolylamine 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 3484-10-4 2-methyl-4-nitro-1H-indole 
• 1262797-40-9 (2-methyl-4-nitro-1H-indol-3-yl)-oxo-acetic acid ethyl ester (4a) 

Relevant articles and documents

Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones

This work investigated the in vitro and in vivo anti-angiogenic activity of some pyrroloazaflavones, exactly 2-phenyl-1H-pyrrolo[2,3-h]quinolin-4(7H)ones, with vinblastine as reference compound. Growth inhibitory activity, migration, and capillary-like structures formation were determined in human umbilical vein endothelial cell cultures, and Matrigel plug assay was carried out to evaluate in vivo effects on angiogenesis. Collectively, our results indicate that some pyrroloazaflavone derivatives, at non-cytotoxic concentrations and like vinblastine are able: (i) to exert in vitro anti-angiogenic activity and (ii) to counteract in vitro and in vivo the pro-angiogenic effects of fibroblast growth factor-2 (FGF-2).

NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF

An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: [wherein [Chemical Formula 2] is a single bond or a double bond; A is -CH2- or -CO-; X, Y, and Z are each independently a nitrogen atom or a carbon atom; R1 is a hydrogen atom or an aralkyl group; R2 is an alkyl group or an aralkyl group, etc.; R3 is a hydrogen atom or an alkyl group, etc.; R4 is a hydrogen atom or an alkyl group; R5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.; R6 is a hydrogen atom or an alkyl group; R7 is a hydrogen atom, etc.; R8 is a hydrogen atom, or an alkyl group, etc.; and E is -NHCO-G-COR12, etc. (wherein G is a single bond or an alkylene group, and R12 is a hydroxy group or an alkoxy group)].

Synthesis of Indoles via Ring Closure of 2-Alkylnitroaniline Derivatives.

A variety of nitroindoles have been prepared from imidate, amidine, and sec-anilide derivatives of 2-alkyl-3- or 5-nitroanilines by a base-induced cyclization promoted by dialkyl oxalates.It is shown that essentially the same procedure also can be used to synthesize the corresponding nitroindole-3-glyoxylates in one simple operation.The synthetic potential is discussed and a mechanism is proposed.