1330531-10-6

Basic information

• Product Name: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester hydrochloride
• Synonyms: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester hydrochloride
• CAS NO: 1330531-10-6
• Molecular Weight: 679.164
• Mol File: 1330531-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester hydrochloride(1330531-10-6)
• EPA Substance Registry System: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester hydrochloride(1330531-10-6)

Safety Data

• Hazardous Substances Data: 1330531-10-6(Hazardous Substances Data)

Upstream product

• 119-67-5 o-carboxybenzaldehyde 
• 380905-48-6 (±)-2-(1-hydroxypentyl)benzoic acid 
• 3413-15-8 butylphthalide 
• 1257642-04-8 (E)-5-bromopentyl 3-(4-hydroxy-3-methoxyphenyl)acrylate 
• 1257641-82-9 (E)-5-(nitrooxy)pentyl 3-(4-hydroxy-3-methoxyphenyl)acrylate 
• 1107060-38-7 (+/-)-2-[1-(2-chloroacetoxy)pentyl]benzoic acid 
• 110-91-8 morpholine 
• 1330531-04-8 (+/-)-(E)-2-(2-chloroacetoxypentyl)benzoic acid {2-methoxy-4-[2-(5-nitrooxypentoxycarbonyl)vinyl]}phenyl ester 

Relevant articles and documents

Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents

Novel nitric oxide (NO) releasing derivatives (7a-7l) of 3-n-butylphthalide (NBP) were designed and synthesized. Compound 7e inhibited the adenosine diphosphate (ADP), thrombin (TH) and arachidonic acid (AA)-induced in vitro platelet aggregation, superior to NBP and aspirin, released moderate levels of NO, and improved aqueous solubility relative to NBP. Furthermore, 7e exhibited greater antithrombotic activity than NBP and aspirin in rats, and protected against collagen and adrenaline-induced thrombosis in mice. Therefore, NO-releasing NBP derivatives possessed potent antiplatelet aggregation and antithrombotic activity. Our findings may aid in the design of new therapeutic agents for the treatment of thrombosis-related ischemic stroke.