133055-05-7

Basic information

• Product Name: (1R,2R)-N,O,o,o-tetramethylpseudoephedrine
• CAS NO: 133055-05-7
• Molecular Weight: 221.343
• Mol File: 133055-05-7.mol

Chemical Properties

• CAS DataBase Reference: (1R,2R)-N,O,o,o-tetramethylpseudoephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-N,O,o,o-tetramethylpseudoephedrine(133055-05-7)
• EPA Substance Registry System: (1R,2R)-N,O,o,o-tetramethylpseudoephedrine(133055-05-7)

Safety Data

• Hazardous Substances Data: 133055-05-7(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 

Relevant articles and documents

TRICARBONYLCHROMIUM(0) PROMOTED STEREOSELECTIVE TRANSFORMATIONS OF EPHEDRINE AND PSEUDOEPHEDRINE DERIVATIVES

(-)-(1S,2S)-(N,O-Dimethylephedrine)tricarbonylchromium(0) (6) and (-)-(1S,2R)-(N,O-dimethylpseudoephedrine)tricarbonylchromium(0) (22) undergo completely stereoselective ortho deprotonation upon treatment with alkyllithium base, followed by addition of an electrophile.In both cases, exclusive remolval of the pro-(R)-ortho proton was confirmed by single X-ray structure analyses of the methylated products.Addition of methyllithium onto the ortho-formylated derivative of complex (6) occurs stereoselectively, the stereochemistry of the major product being confirmed by a single crystal X-ray structure determination.The results presented demonstrate an efficient transfer of chirality from a side chain onto the (arene)tricarbonylchromium(0) complex and back to a different side chain.