1330573-99-3Relevant academic research and scientific papers
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists
éles, János,Beke, Gyula,Vágó, István,Bozó, éva,Huszár, József,Tarcsay, ákos,Kolok, Sándor,Schmidt, éva,Vastag, Mónika,Hornok, Katalin,Farkas, Sándor,Domány, Gy?rgy,Keser, Gy?rgy M.
, p. 3095 - 3099 (2012/06/17)
A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.
Pd-catalyzed sequential C-C and C-N bond formations for the synthesis of N-heterocycles: Exploiting protecting group-directed C-H activation under modified reaction conditions
Kim, Byung Seok,Lee, Sun Young,Youn, So Won
, p. 1952 - 1957 (2011/11/04)
Easy & efficient: A Pd-catalyzed domino olefination/conjugate addition reaction of N-Ts-2-arylanilines with activated olefins has been achieved at ambient temperature under the newly defined reaction conditions. This process highlighted the directing effect of the N-protecting group in C-H activation, displayed broad substrate scope with wide functional group compatibility; thus rendering a straightforward entry to a wide variety of N-heterocycles such as dihydrophenanthridines.
Highly effective Pd-catalyzed ortho olefination of acetanilides: Broad substrate scope and high tolerability
Kim, Byung Seok,Jang, Chungsik,Lee, Dong Jin,Youn, So Won
supporting information; scheme or table, p. 2336 - 2340 (2011/06/25)
Bring it on! An effective Pd-catalyzed ortho olefination of various acetanilides has been developed. This transformation has a broad substrate scope and wide functional-group tolerability, regardless of the electronic and steric properties of acetanilide substrates, providing a straightforward access to highly functionalized arenes.
