1330593-67-3

Upstream product

• 13526-66-4 3-bromo-6-chloro-imidazo[1,2-b]pyridazine 
• 1330595-43-1 tert-butyl {trans-4-[(3-bromoimidazo[1,2-b]pyridazin-6-yl)amino]cyclohexyl}carbamate 
• 1330595-44-2 tert-butyl [trans-4-({3-[2-(methylsulfanyl)pyrimidin-5-yl]imidazo-[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate 
• 2615-25-0 trans-1,4-cyclohexyldiamine 
• 1330595-45-3 tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate 

Relevant academic research and scientific papers

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

A series of imidazopyridazines which are potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was identified from a high-throughput screen against the isolated enzyme. Subsequent exploration of the SAR and optimisation has yielded leading members which show promising in vitro anti-parasite activity along with good in vitro ADME and selectivity against human kinases. Initial in vivo testing has revealed good oral bioavailability in a mouse PK study and modest in vivo efficacy in a Plasmodium berghei mouse model of malaria.