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1330624-42-4

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1330624-42-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1330624-42-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,0,6,2 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1330624-42:
(9*1)+(8*3)+(7*3)+(6*0)+(5*6)+(4*2)+(3*4)+(2*4)+(1*2)=114
114 % 10 = 4
So 1330624-42-4 is a valid CAS Registry Number.

1330624-42-4Downstream Products

1330624-42-4Relevant articles and documents

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)

Engers, Darren W.,Blobaum, Anna L.,Gogliotti, Rocco D.,Cheung, Yiu-Yin,Salovich, James M.,Garcia-Barrantes, Pedro M.,Daniels, J. Scott,Morrison, Ryan,Jones, Carrie K.,Soars, Matthew G.,Zhuo, Xiaoliang,Hurley, Jeremy,Macor, John E.,Bronson, Joanne J.,Conn, P. Jeffrey,Lindsley, Craig W.,Niswender, Colleen M.,Hopkins, Corey R.

, p. 1192 - 1200 (2016/10/03)

The efficacy of positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 4 (mGlu4) in preclinical rodent models of Parkinson's disease has been established by a number of groups. Here, we report an advanced preclinically characterized mGlu4 PAM, N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506). We detail the discovery of VU0418506 starting from a common picolinamide core scaffold and evaluation of a number of amide bioisosteres leading to the novel pyrazolo[4,3-b]pyridine head group. VU0418506 has been characterized as a potent and selective mGlu4 PAM with suitable in vivo pharmacokinetic properties in three preclinical safety species.

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