133071-07-5Relevant articles and documents
Isolation and Structure Elucidation of Ergokonin A and B; Two New Antifungal Sterol Antibiotics from Trichoderma koningii
Augustiniak, Hermann,Forche, Edgar,Reichenbach, Hans,Wray, Viktor,Graefe, Udo,Hoefle, Gerhard
, p. 361 - 366 (2007/10/02)
Isolation and structure elucidation by 2D-NMR spectroscopy of the two new antifungal sterol antibiotics ergokonin A (1) and B (2a) from Trichoderma koningii are described.The structures of 1 and 2a are derived from ergosterol and characterized by an 18-carboxy group.In addition ergokonin A (1) is esterified at the 3-hydroxy group with (2S,3S)-3-hydroxyleucine 3-O-sulfate (3c).In the course of structure elucidation of the amino acid residue the stereoisomers of 3-hydroxyleucine N-sulfamate and 3-O-sulfate (3b, c) have been synthesized and characterized by NMR spectroscopy.