1330786-88-3Relevant academic research and scientific papers
Copper-Catalyzed Oxy-aminomethylation of Diazo Compounds with N, O-Acetals
Yu, Jianliang,Chen, Long,Sun, Jiangtao
, p. 1664 - 1667 (2019)
A novel oxy-aminomethylation reaction of diazo compounds has been developed, providing the α-hydroxy-β2-amino acid derivatives with quaternary carbon centers in moderate to excellent yields. Importantly, the readily available N,O-acetals have been employed as efficient bifunctionalization reagents to react with copper carbene intermediates, leading to the concurrent incorporation of an alkoxy and an iminium group into one molecule. Moreover, a water-involved three-component reaction occurs to deliver the free-hydroxy amino acid derivatives.
Regiospecific epoxide opening: A facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives
Chouhan, Mangilal,Senwar, Kishna Ram,Sharma, Ratnesh,Grover, Vikas,Nair, Vipin A.
, p. 2553 - 2560 (2011/10/12)
A mild and eco-friendly method has been developed for aminolysis of 3-oxirane-indolin-2-ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones. An enhancement in reaction rate was observed when water was used as the reaction medium. The reactions proceed regiospecifically to open the epoxide ring from the less-substituted end.
