133091-81-3

Basic information

• Product Name: 7-Quinolinamine,5,6,7,8-tetrahydro-(9CI)
• Synonyms: 7-Quinolinamine,5,6,7,8-tetrahydro-(9CI);5,6,7,8-Tetrahydroquinolin-7-aMine
• CAS NO: 133091-81-3
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Product Categories: PYRIDINE;AMINEPRIMARY
• Mol File: 133091-81-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 264.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.081±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.00±0.20(Predicted)
• CAS DataBase Reference: 7-Quinolinamine,5,6,7,8-tetrahydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Quinolinamine,5,6,7,8-tetrahydro-(9CI)(133091-81-3)
• EPA Substance Registry System: 7-Quinolinamine,5,6,7,8-tetrahydro-(9CI)(133091-81-3)

Safety Data

• Hazardous Substances Data: 133091-81-3(Hazardous Substances Data)

Usage

General Description

7-Quinolinamine, 5,6,7,8-tetrahydro, also known as tetrahydroquinoline, is a chemical compound with the molecular formula C9H11N. It is a heterocyclic compound with a bicyclic structure and is classified as a quinoline derivative. This chemical is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential as an anti-cancer agent and for its antimicrobial properties. Additionally, tetrahydroquinoline derivatives have shown potential as antioxidants and as inhibitors of acetylcholinesterase, making them of interest for the treatment of neurodegenerative diseases. Overall, 7-Quinolinamine, 5,6,7,8-tetrahydro is a versatile compound with a range of potential applications.

Upstream product

• 24334-23-4 5,6-dihydroquinoline 
• 185510-52-5 5-(N-acetylamino)-5,6,7,8-tetrahydroquinoline 
• 298182-09-9 N-(5,6,7,8-tetrahydroquinolin-7-yl)acetamide 
• 133092-40-7 N-(1-Phenyl-ethyl)-N-(5,6,7,8-tetrahydro-quinolin-7-yl)-hydroxylamine 
• 138589-23-8 O-Benzyl-N-(5,6,7,8-tetrahydro-quinolin-7-yl)-hydroxylamine 

Downstream Products

• 405058-77-7 {4-[(5,6,7,8-Tetrahydro-quinolin-7-ylamino)-methyl]-benzyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Chemokine receptor binding heterocyclic compounds

This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines. The present invention provides a compound of Formula I wherein, W is a nitrogen atom and Y is absent or, W is a carbon atom and Y═H; R1to R7may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C1-6alkyl; R8is a substituted heterocyclic group or a substituted aromatic group Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and n′ are independently, 0-2; X is a group of the formula: Wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom. Ring B is an optionally substituted 5 to 7-membered ring. Ring A and Ring B in the above formula can be connected to the group W from any position via the group V, wherein V is a chemical bond, a (CH2)n″group (where n″=0-2) or a C═O group. Z is, (1) a hydrogen atom, (2) an optionally substituted C1-6alkyl group, (3) a C0-6alkyl group substituted with an optionally substituted aromatic or heterocyclic group, (4) an optionally substituted C0-6alkylamino or C3-7cycloalkylamino group, (5) an optionally substituted carbonyl group or sulfonyl. These compounds further include any pharmaceutically acceptable acid addition salts and metal complexes thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof.

7-Amino-5,6,7,8-tetrahydroquinolines. Preparation from 5,6-dihydroquinoline and nitrogen nucleophiles

The preparation of 7-amino-5,6,7,8-tetrahydroquinolines is described. These agents are 5-HT(1A) receptor ligands related to 8-OH-DPAT.