133098-04-1Relevant articles and documents
Preparation of the Isoflurane Enantiomers
Huang, Chialang G.,Rozov, Leonid A.,Halpern, Donald F.,Vernice, Gerald G.
, p. 7382 - 7387 (2007/10/02)
The enantiomers of the inhalation anesthetic agent, isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether), are prepared by a synthesis starting from 2,2,2-trifluoroethanol. (R)-(+)-Dehydroabietylamine is used as the resolving agent for the racemic acid intermediate 1.The optical purities of both (S)-(+)- and (R)-(-)-isofluranes are determined to be >99percent ee (enantiomeric excess) by chiral capillary gas chromatography.