133100-18-2Relevant academic research and scientific papers
Receptor-based design of novel dihydrofolate reductase inhibitors: Benzimidazole and indole derivatives
Ohemeng,Roth
, p. 1383 - 1394 (2007/10/02)
Although many thousands of inhibitors of the enzyme dihydrofolate reductase (DHFR) have been synthesized, all of the very active compounds have been 2,4-diaminopyrimidines or very close analogues. This paper describes 2,4-diamino-6-benzylbenzimidazole (3b
