133110-30-2Relevant academic research and scientific papers
SUBSTITUTED PYRROLE COMPOUNDS AND USE THEREOF IN PHARMACEUTICAL COMPOSITIONS
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, (2008/06/13)
The invention concerns substituted pyrrole compounds and their pharmaceutical applications. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo-oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments. The compounds have the general formula: STR1 where R1 denotes a C1 -C12 alkyl group, R2 denotes a hydrogen atom or a C1 -C12 alkyl group, or R1 and R2 together with the carbon atom and the nitrogen atom to which they are bound form a ring of 5 to 8 links which may contain a sulfur heteroatom or a carbonyl group and may be substituted with one or two C1 -C4 alkyl groups, each time two of the residues R3, R4 and R5 independently from one another represent a hydrogen atom, a C5 -C8 cycloalkyl group, a C1 -C12 alkyl group or an aryl group which may be substituted by one or two residues selected from a halogen atom, a nitro-, a C1 -C4 alkoxy-, a hydroxy-, a C1 -C4 alkyl- or phenoxy-group, and where the third of the residues R3, R4 and R5 denotes --CHO, --CO2 H, --COSC1 -C4 -alkyl or A--X, with A being a straight-chain or a branched C1 -C8 alkylene group which may be interrupted by an oxygen heteroatom or a carbonyl group or being a C2 -C8 alkenylene group, X being CO2 H, SO3 H, CHO, OH or SH, as well as their pharmaceutically compatible salts and esters, for pharmaceutical applications.
