133118-28-2

Upstream product

• 133118-32-8 N-ethyl-N-phenyl-4-(methylthio)-3H-1,5-benzodiazepin-2-amine 
• 613-94-5 benzoic acid hydrazide 
• 134801-05-1 2,4-bis(methylthio)-3H-1,5-benzodiazepine 
• 69540-74-5 dimethyl-(4-methylsulfanyl-3H-benzo[b][1,4]diazepin-2-yl)-amine 
• 69540-75-6 diethyl-(4-methylsulfanyl-3H-benzo[b][1,4]diazepin-2-yl)-amine 
• 69540-76-7 2-methylsulfanyl-4-pyrrolidin-1-yl-3H-benzo[b][1,4]diazepine 
• 95-54-5 1,2-diamino-benzene 
• 62537-65-9 4-(N-ethyl-anilino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 134801-02-8 1H-1,5-benzodiazepine-2,4(3H,5H)-dithione 
• 49799-48-6 1H-1,5-benzodiazepine-2,4(3H,5H)-dione 

Downstream Products

• 868241-85-4 C₂₃H₁₅ClN₆ 

Relevant academic research and scientific papers

RECHERCHES EN SERIE BENZODIAZEPINE-1,5: SYNTHESES DES DITRIAZOLO--BENZODIAZEPINES-1,5

The action of several o-phenylenediamines on malonic acid was studied.Six new ditriazolo-1,5-benzodiazepines were prepared from 1,5-benzodiazepin-2,4-diones.Their structures are supported by 1H nmr,ir, mass spectrometry and elemental analysis.

1,5-Benzodiazepines VIII. Novel 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine derivatives with analgesic or anti-inflammatory activity

The reaction of N,N-disubstituted 4-(methylthio)-3H-1,5-benzodiazepin-2-amines 8 with formylhydrazine, acetylhydrazine or benzoylhydrazine afforded the expected N,N-disubstituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines 9, along with lower yields of tetracyclic compounds 10. A number of compounds 9 and 10 were tested for their analgesic, anti-inflammatory and anticonvulsant activities, as well as for their acute toxicity and gross behavioral effects. Dipyrone, indomethacin and phenobarbital were used as reference drugs. Some compounds 9 showed statistically significant analgesic or anti-inflammatory properties, depending on the structure.