133118-46-4

Basic information

• Product Name: 2-<2-(2,3-difluorophenyl)-4-imidazolyl>ethanamine
• CAS NO: 133118-46-4
• Molecular Weight: 223.225
• Mol File: 133118-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-<2-(2,3-difluorophenyl)-4-imidazolyl>ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<2-(2,3-difluorophenyl)-4-imidazolyl>ethanamine(133118-46-4)
• EPA Substance Registry System: 2-<2-(2,3-difluorophenyl)-4-imidazolyl>ethanamine(133118-46-4)

Safety Data

• Hazardous Substances Data: 133118-46-4(Hazardous Substances Data)

Upstream product

• 65465-66-9 2-Oxo-4-phthalimido-1-butyl acetate 

Relevant articles and documents

Histamine analogues. 33rd communication: 2-phenylhistamines with high histamine H1-agonistic activity

2-Phenylhistamines with various substituents at the phenyl ring were synthesized and the influence of substitution in ortho, meta or para position on histamine H1-agonistic activity was investigated.Compounds with high activity occured in the meta phenyl series.Increased activity in the guinea-pig ileum assay was achieved by monosubstitution with halogen on the phenyl ring. 2-ethanamine (12) is the most potent highly selective H1-agonist known so far, showing 87percent relative potency compared with histamine and full efficacy at theH1-receptor.Relative activities of the 3-chloro analogue (11) and the 3-methyl analogue (13) are 81percent and 29percent, respectively.Histamine H2-activity could not be detected. 2-Phenylhistamines are available via reaction of the corresponding benzimidates with 2-oxo-4-phthalimido-1-butyl acetate (6) in liquid ammonia.