133124-61-5Relevant academic research and scientific papers
Irreversible, tight-binding inhibition of adenosine deaminase by coformycins: Inhibitor structural features that contribute to the mode of enzyme inhibition
Hong, Mikyung,Hosmane, Ramachandra S.
, p. 1053 - 1057 (1997)
Coformycin analogues 1-6 were synthesized and biochemically screened against adenosine deaminase in order to assess the relative contributions of N-4, N-6, and the N-3 sugar moiety to the mode of enzyme inhibition. Our results indicate that N-4 plays a relatively greater role than N-6 in enzyme tight-binding, and that a benzyl group can substitute for the sugar moiety at N-3. The absence of a sugar or benzyl group at N-3, however, leads to loss of activity. The hydroxyl group at C-8, while crucial for activity, does not alone confer the tight-binding characteristics to coformycins.
The Synthesis of Ring-expanded Analogues of Xanthine Containing the Imidazodiazepine Ring System
Hosmane, Ramachandra S.,Bhan, Anila
, p. 2189 - 2196 (2007/10/02)
The synthesis of 4,5,7,8-tetrahydro-6H-imidazodiazepine-5,8-dione and its several 1- and 3-alkyl (aralkyl) derivatives 2 has been reported.Mechanistic explorations of the final synthetic step as well as structural confirmation of a final produ
