133131-90-5Relevant academic research and scientific papers
4-aminoquinoline compound, and preparation method and application thereof
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Paragraph 0032; 0043-0046, (2019/11/12)
The invention discloses a 4-aminoquinoline compound, and a preparation method and application thereof. The second site of the 4-aminoquinoline compound is replaced by cyclic R-base, the 4-aminoquinoline compound is obtained by 4-step reaction of anthranil
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Pinard, Emmanuel,Alanine, Alexander,Bourson, Anne,Buettelmann, Bernd,Heitz, Marie-Paule,Mutel Ramanjit Gill, Vincent,Trube, Gerhard,Wyler, Rene
, p. 2615 - 2619 (2007/10/03)
Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.
The Vilsmeier cyclization of 2′-azido and 2′-aminochalcones - A mild one pot synthesis of 2-aryl-4-chloroquinoline and its N-formyl-1,2-dihydro derivatives
Akila, Shanmugam,Selvi, Srinivasan,Balasubramanian, Krishna
, p. 3465 - 3469 (2007/10/03)
The Vilsmeier cyclization of 2′-aminochalcones provides a mild one pot synthesis of 2-aryl-4-chloro-N-formyl-1,2-dihydroquinolines. The scope of the reaction has been extended for the synthesis of quinolines themselves, by replacing 2′-aminochalcones with 2′-azidochalcones as the starting material. The yields are reasonably good and a plausible mechanism for the formation of the products in each case has been discussed.
