133141-78-3

Upstream product

• 141-75-3 butyryl chloride 
• 133142-08-2 4'-(5-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid 
• 133139-74-9 tert.butyl 4'-[(2-n-butyl-5-butanoylamino-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate 

Relevant academic research and scientific papers

Angiotensin II - AT1 receptor antagonists: Design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives

A series of 5-(alkyl and aryl)carboxamido benzimidazole derivatives had been designed, synthesized and evaluated for in vitro angiotensin II - AT1 receptor antagonism and in vivo antihypertensive activities. The pharmacological activities were inversely related to the size of alkyl and aryl substituents. It can be suggested that compounds with lower alkyl groups at 5-position of benzimidazole nucleus demonstrated potent antihypertensive activity.

Benzimidazoles and medicaments containing these compounds

The invention relates to benzimidazoles of the formula STR1 in which R1 to R2 are as defined in claim 1, 1 and 3 isomer mixtures thereof and addition salts thereof which have valuable properties. In particular, the novel compounds ar