13316-12-6

Basic information

• Product Name: 7-chlorothiazolo[5,4-d]pyrimidine
• Synonyms: 7-chlorothiazolo[5,4-d]pyrimidine;Thiazolo[5,4-d]pyriMidine, 7-chloro-
• CAS NO: 13316-12-6
• Molecular Formula: C₅H₂ClN₃S
• Molecular Weight: 171.61
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 13316-12-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 152-154℃
• Boiling Point: 295℃
• Flash Point: 132℃
• Appearance: /
• Density: 1.639
• Vapor Pressure: 0.00274mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 7-chlorothiazolo[5,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chlorothiazolo[5,4-d]pyrimidine(13316-12-6)
• EPA Substance Registry System: 7-chlorothiazolo[5,4-d]pyrimidine(13316-12-6)

Safety Data

• Hazardous Substances Data: 13316-12-6(Hazardous Substances Data)

Usage

General Description

7-Chlorothiazolo[5,4-d]pyrimidine is a chemical compound with the molecular formula C5H2ClN3S. It is a heterocyclic organic compound that contains both chlorine and nitrogen atoms. 7-chlorothiazolo[5,4-d]pyrimidine is a potential building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a key intermediate in the production of various bioactive compounds, including fungicides and antiviral drugs. The structure of 7-chlorothiazolo[5,4-d]pyrimidine makes it a versatile compound for use in various chemical reactions and in the development of new drugs and agrochemicals.

InChI:InChI=1/C5H2ClN3S/c6-4-3-5(8-1-7-4)10-2-9-3/h1-2H

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 54851-35-3 4-chloro-5-amino-6-mercaptopyrimidine 
• 5021-50-1 6H-thiazolo[5,4-d]pyrimidin-7-one 

Downstream Products

• 1023758-28-2 N-(4-(thiazolo[5,4-d]pyrimidin-7-ylamino)phenyl)benzamide 
• 1420829-90-8 C₂₆H₁₉N₇OS 
• 1420830-03-0 C₂₇H₂₁N₇OS 
• 1420829-04-4 C₂₆H₂₁N₇OS 
• 1420829-13-5 C₂₈H₁₉F₃N₆OS 
• 1420829-02-2 C₂₂H₁₆ClN₅OS 

Relevant articles and documents

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.