1331752-69-2

Upstream product

• 796038-69-2 2-Methyl-propane-2-sulfinic acid [(1R,2R)-2-(benzyl-hydroxy-amino)-3-methyl-1-phenyl-butyl]-amide 
• 796038-88-5 2-Methyl-propane-2-sulfinic acid ((1R,2R)-2-benzylamino-3-methyl-1-phenyl-butyl)-amide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1331752-68-1 C₂₃H₃₂N₂O₂ 
• 196929-85-8 (R)-N-benzylidene-2-methylpropane-2-sulfinamide 

Downstream Products

• 1331752-70-5 C₁₈H₂₄N₂O₂S 

Relevant academic research and scientific papers

Ruthenium(II)-catalyzed asymmetric transfer hydrogenation using unsymmetrical vicinal diamine-based ligands: Dramatic substituent effect on catalyst efficiency

The use of unsymmetrical vicinal diamines as ligands for Ru-catalyzed asymmetric transfer hydrogenation is described. With a SmI2-mediated cross-coupling protocol, a series of enantiomerically pure unsymmetrical vicinal diamines were readily prepared and examined in the asymmetric transfer hydrogenation. It was found that an aromatic substituent on the carbon bearing the-NHTs group and a bulky alkyl substituent on the other side, are both very important for the effectiveness of the ligand, suggesting that the substituent has a dramatic effect on the catalyst efficiency. With ligand 8, excellent enantioselectivities that are comparable to N-tosyl-1,2-diphenylethane-1,2- diamine (TsDPEN) were achieved. The results provide some helpful information on the mechanism of Ru-catalyzed asymmetric transfer hydrogenation. A series of unsymmetrical vicinal diamines were prepared and examined as chiral ligands for Ru-catalyzed asymmetric transfer hydrogenation.