1331777-58-2Relevant academic research and scientific papers
Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement
Tuyishime, Marina,Lawrence, Rae,Cocklin, Simon
, p. 228 - 234 (2016)
Demand remains for new inhibitors of HIV-1 replication and the inhibition of HIV-1 entry is an extremely attractive therapeutic approach. Using field-based bioisosteric replacements, we have further extended the chemotypes available for development in the HIV-1 entry inhibitor class. Moreover, using field-based disparity analysis of the compounds, 3D structure-activity relationships were derived that will be useful in the further development of these inhibitors towards clinical utility.
