1331783-45-9Relevant academic research and scientific papers
Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: Facile construction of pharmaceutically analogous bis-alkaloid scaffolds
Chu, Xue-Qiang,Wang, Shun-Yi,Ji, Shun-Jun
, p. 8380 - 8387 (2013/09/02)
An efficient sodium hydrogen sulfate catalyzed alkylation of indoles or amines with tertiary enamides has been accomplished in water, affording the pharmacologically and biologically active 2-oxo-1-pyrrolidine derivatives in moderate to excellent yields. The key to our success is the use of NaHSO 4 as a low loading, inexpensive, green and recyclable catalyst and the reactions could be scaled up to gram level.
Direct alkylation of indoles and amines by tert-enamides: Facile access to pharmaceutically active 2-oxo-1-pyrrolidine analogues
Jiang, Ran,Xu, Hai-Yan,Xu, Xiao-Ping,Chu, Xue-Qiang,Ji, Shun-Jun
supporting information; experimental part, p. 5659 - 5669 (2011/09/15)
Direct alkylation of indoles and amines by tertiary enamides for the synthesis of pharmaceutically active 2-oxo-1-pyrrolidine analogues was described. With only a 0.5 mol% catalyst loading, molecular iodine was demonstrated to be efficiently enough to promote the reaction under neat condition. Only Markovnikov addition product was obtained indicating that the reactions proceeded with excellent regioselectivity.
