133181-53-0

Basic information

• Product Name: methyl 7-oxo-3α,6α,12α-trihydroxy-5β-cholanoate
• Synonyms: methyl 7-oxo-3α,6α,12α-trihydroxy-5β-cholanoate
• CAS NO: 133181-53-0
• Molecular Weight: 436.589
• Mol File: 133181-53-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 7-oxo-3α,6α,12α-trihydroxy-5β-cholanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7-oxo-3α,6α,12α-trihydroxy-5β-cholanoate(133181-53-0)
• EPA Substance Registry System: methyl 7-oxo-3α,6α,12α-trihydroxy-5β-cholanoate(133181-53-0)

Safety Data

• Hazardous Substances Data: 133181-53-0(Hazardous Substances Data)

Upstream product

• 911-40-0 7-ketodeoxycholic acid 
• 10452-63-8 methyl 6α-bromo-3α,12α-acetoxy-7-oxo-5β-cholanoate 

Relevant articles and documents

POLYHYDROXYLATED BILE ACIDS FOR TREATMENT OF BILIARY DISORDERS

The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis or portal hypertesion. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2α,3α,7α,12α-tetrahydroxy-5β-cholanoic acid and 3α,4α,7α,12α-tetrahydroxy-5β-cholanoic acid are disclosed, uses thereof and synthesis thereof.

Potential bile acid metabolites. 16. Synthesis of stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids

New synthetic routes to the four possible stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids (and their methyl esters), one of which (3α,6α,7β,12α) is new, and some related compounds are described.In addition, the 5α-epimer of the new acid was obtained.The final products were obtained in high purity for use as reference compounds in the analysis of bile acids in human biologic samples.The results of analysis of the prepared stereoisomers by proton and carbon 13 nuclear magnetic resonance spectroscopies are briefly discussed along with the thin-layer and gas-liquid chromatographic properties.