1331867-58-3

Basic information

• Product Name: C₂₁H₂₄O₅S
• Synonyms: C₂₁H₂₄O₅S
• CAS NO: 1331867-58-3
• Molecular Weight: 388.485
• Mol File: 1331867-58-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄O₅S(1331867-58-3)
• EPA Substance Registry System: C₂₁H₂₄O₅S(1331867-58-3)

Safety Data

• Hazardous Substances Data: 1331867-58-3(Hazardous Substances Data)

Upstream product

• 120-92-3 cyclopentanone 
• 611-99-4 4,4'-Dihydroxybenzophenone 
• 4239-10-5 2-bromoethyl methanesulfonate 
• 66422-10-4 1,1-bis(4-hydroxyphenyl)methylenecyclopentane 

Downstream Products

• 1242078-05-2 C₂₀H₂₁⁽¹⁸⁾FO₂ 

Relevant articles and documents

Synthesis and evaluation of fluoroethyl cyclofenil analogs: Models for potential estrogen receptor imaging agent

Cyclofenil analogs (2a-2f) and their fluorine-containing derivatives (3a-3f) were synthesized and evaluated as candidate ligands for positron emission tomography (PET) imaging of estrogen receptors. Most of them show relatively high binding affinities comparable with estradiol (E2). (4-Fluoroethoxyphenyl)-(4-hydroxyphenyl) methylenecyclopentane (3a) showed both the highest binding affinity for ERs (88.6 for ERβ, 13.8 for ERα) and highest β/α ratio (β/α for 6.4-fold). The radioactive compound [18F]3a was prepared via displacement of the corresponding mesylate precursor 4 with [18F]fluoride (18F: β+; 96.7%, T1/2 = 109.8 min). The biodistribution studies in immature female SD rats demonstrated that the uptake in the uterus and ovaries were 1.358 ± 0.089% ID/g, 1.439 ± 0.214% ID/g, respectively, both of the ratios of uterus/blood and ovaries/blood was less than 2:1. Micro-PET imaging of immature female SD rats has also been reported.