133196-65-3

Upstream product

• 2985-39-9 2-benzylmalonic acid monoethyl ester 
• 2812-46-6 proline tert-butyl ester 

Downstream Products

• 129505-57-3 HO-m(R,S)Phe-Pro-OBu^t 
• 129505-56-2 H-Tyr-D-Ala-Phe-Gly-ψ(NHCO)-Phe-Pro-OH 
• 129505-66-4 Boc-Tyr(Bu^t)-D-Ala-Phe-Gly-ψ(NHCO)Phe-Pro-OBu^t 

Relevant academic research and scientific papers

Opioid peptides. Synthesis and biological properties of demorphin related hexapeptides

The Gly4 and/or Tyr5 residues in dermorphin hexapeptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-OH) were replaced by Nα-methyl- or D-amino acids in order to examine the effect on opioid activity. Two pseudopeptides (H-Tyr-D-Ala-Phe-Gly-ψ (NHCO)-Xaa-Pro-OH, Xaa - Tyr or Phe) in which the Gly4-Xaa bond is reversed, were also prepared. Metabolic stability, analgesia and selectivity of these compounds for different receptor populations have been investigated. Results suggest that the 12 new analogues showed a negligible affinity for the K binding site and some selectivity for μ- or δ receptors. In some cases the analgesic potencies seems to be related to enzymatic stability of the peptides.

HYDROXYCARBAMOYLALKYLACYLPIPECOLIC ACID COMPOUNDS

New hydroxycarbamoylalkylacyl derivatives of pipecolic acid which have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.

CARBOXYACYLPROLINE DERIVATIVES

New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.