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133210-96-5

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133210-96-5 Usage

Uses

7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride is an impurity in the synthesis of Ciprofloxacin (C482500), a fluorinated quinolone antibacterial.

Check Digit Verification of cas no

The CAS Registry Mumber 133210-96-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,2,1 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133210-96:
(8*1)+(7*3)+(6*3)+(5*2)+(4*1)+(3*0)+(2*9)+(1*6)=85
85 % 10 = 5
So 133210-96-5 is a valid CAS Registry Number.

133210-96-5Downstream Products

133210-96-5Relevant articles and documents

Quinolone antibiotics: Study of reactivity and impurity profile of piperazine with chloro-fluoro-quinolone carboxylic acid in aqueous medium

Kalkote,Sathe,Kharul,Chavan,Ravindranathan

, p. 6785 - 6786 (1996)

The reaction of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,2-dihydroquinoline-3-carboxyli c acid with piperazine in water was studied. The product ciprofloxacin was isolated and the impurity formed in the reaction was isolated and characterized as 1-cyclopropyl-7-chloro-6-piperazinyl-4-oxo-1,2-dihydroquinoline-3-carb oxylic acid. Similarly norfloxacin was also synthesised.

Convenient one pot synthesis of some fluoroquinolones in aqueous media

Abaee, M. Saeed,Sharifi, Ruhollah,Borhani, Shahin,Heravi, Majid M.,Motahari, Hossein

, p. 415 - 418 (2005)

A one pot synthetic strategy for the preparation of fluoroquinolones from 1 is introduced. Product 3 was condensed with piperazine in an aqueous media to produce pharmaceutical grade ciprofloxacin in 86% yield. The method was extended to the synthesis of some other fluoroquinolones with pharmaceutical grade quality.

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