1332303-41-9Relevant academic research and scientific papers
Total syntheses of chaetocin and ent-chaetocin
Iwasa, Eriko,Hamashima, Yoshitaka,Fujishiro, Shinya,Hashizume, Daisuke,Sodeoka, Mikiko
, p. 6587 - 6599 (2011)
The first total synthesis of chaetocin (1), a potent histone methyltransferase inhibitor, is described in detail. Key reactions were radical bromination for α-oxidation of the diketopiperazine ring, and reductive radical coupling for construction of the d
Total synthesis of (+)-chaetocin and its analogues: Their histone methyltransferase g9a inhibitory activity
Iwasa, Eriko,Hamashima, Yoshitaka,Fujishiro, Shinya,Eisuke, Higuchi,Ito, Akihiro,Yoshida, Minoru,Sodeoka, Mikiko
supporting information; scheme or table, p. 4078 - 4079 (2010/05/15)
Chemical Equation Presentation The first total synthesis of (+)-chaetorin has been accomplished in only nine steps starting from the known N-Cbz-N-Me-serie using radical α-bromlnatlon reaction of diketopiperazine 10 and Co(I)-mediated reductive dimerizati
