1332329-75-5

Upstream product

• 1143490-94-1 N-[(2-benzoyloxy-1-tosyl)ethyl]urea 
• 1332329-74-4 N-[(1-benzoyloxy-4-oxo-4-phenyl-3-tosyl)but-2-yl]urea 
• 31378-03-7 1-phenyl-2-tosylethanone 

Downstream Products

• 1332329-77-7 4-(mesyloxymethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one 
• 1332329-78-8 4-(chloromethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one 
• 1332329-76-6 4-(hydroxymethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one 
• 1332329-80-2 4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one 
• 1332329-81-3 7-phenyl-4-phenylthio-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one 
• 1332329-82-4 4-cyano-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one 
• 1332329-83-5 7-phenyl-4-phthalimido-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one 

Relevant academic research and scientific papers

Nucleophile-mediated ring expansion of 4-chloromethyl- and 4-mesyloxymethyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-ones to 6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-ones: Effect of the leaving group and the substituent at C6

A five-step synthesis of 4-chloromethyl- and 4-mesyloxymethyl-5-tosyl-1,2, 3,4-tetrahydropyrimidin-2-ones has been developed. The reaction of N-[(2-benzoyloxy-1-tosyl)ethyl]urea with sodium enolates of α-tosylketones followed by cyclization-dehydration, a