1332344-63-4Relevant academic research and scientific papers
Tricomponent catalytic α,α-difluorination of acid chlorides
Bloom, Steven,Scerba, Michael T.,Erb, Jeremy,Lectka, Thomas
supporting information; experimental part, p. 5068 - 5071 (2011/11/29)
The selective α,α-difluorination of carbonyl compounds remains a challenge in modern organic synthesis; current methods often incorporate stepwise processes and/or harsh conditions, providing unsatisfactory mixtures of mono- and difluorinated products. In this communication, a practical, mild, and one-pot method for the selective α,α-difluorination of readily available acid chlorides is reported in which three separate catalysts act synergistically to form products in outstanding selectivity and fair to excellent yields.
