1332375-47-9Relevant academic research and scientific papers
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors
Verma, Vishal A.,Rossman, Randall,Bennett, Frank,Chen, Lei,Gavalas, Stephen,Girijavallabhan, Vinay,Huang, Yuhua,Kim, Seong-Heon,Kosinski, Aneta,Pinto, Patrick,Rizvi, Razia,Shankar, Bandarpalle,Tong, Ling,Velazquez, Francisco,Venkatraman, Srikanth,Kozlowski, Joseph,MacCoss, Malcolm,Li, Cheng,Chase, Robert,Curry, Stephanie,Huang, Hsueh-Cheng,Tong, Xiao,Njoroge, F. George,Arasappan, Ashok,Kwong, Cecil D.,Bansal, Namita,Kezar III, Hollis S.,Reynolds, Robert C.,Maddry, Joseph A.,Ananthan, Subramaniam,Secrist III, John A.
, p. 6967 - 6973,7 (2020/09/02)
The installation of geminal substitution at the C5′ position of the carbosugar in our pyrimidine-derived hepatitis C inhibitor series is reported. SAR studies around the C5′ position led to the installation of the dimethyl group as the optimal functionali
