1332454-07-5 Usage
Biochem/physiol Actions
PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.
Check Digit Verification of cas no
The CAS Registry Mumber 1332454-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,2,4,5 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1332454-07:
(9*1)+(8*3)+(7*3)+(6*2)+(5*4)+(4*5)+(3*4)+(2*0)+(1*7)=125
125 % 10 = 5
So 1332454-07-5 is a valid CAS Registry Number.
1332454-07-5Relevant articles and documents
TASK CHANNEL ANTAGONISTS
-
, (2011/09/21)
This invention relates to TASK-1 and/or TASK-3 antagonists and/or their pharmaceutically acceptable salts, compositions and methods for treating and preventing disorders which are caused by activation or by an activated TASK-1 and/or TASK-3, and disorders
