1332482-87-7Relevant academic research and scientific papers
High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl) benzimidazole as a highly antimycotic agent nontoxic to cell lines
Bauer, J?rg,Kinast, Stephan,Burger-Kentischer, Anke,Finkelmeier, Doris,Kleymann, Gerald,Rayyan, Walid Abu,Schr?ppel, Klaus,Singh, Anurag,Jung, Günther,Wiesmüller, Karl-Heinz,Rupp, Steffen,Eickhoff, Holger
, p. 6993 - 6997 (2011/12/04)
Novel nontoxic (S)-2-aminoalkylbenzimidazole derivatives were found to be effective against Candida spp. at low micromolar concentrations using high-throughput screening with infected HeLa cells. A collection of analogues defined the chemical groups relevant for activity. The most active compound was characterized by transcriptional analysis of the response of C. albicans Sc5314. (S)-2-(1-Aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole had a strong impact on membrane biosynthesis. Testing different clinically relevant pathogenic fungi showed the selectivity of the antimycotic activity against Candida species.
