1332523-77-9

Basic information

• Product Name: (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol
• Synonyms: (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol
• CAS NO: 1332523-77-9
• Molecular Weight: 333.307
• Mol File: 1332523-77-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol(1332523-77-9)
• EPA Substance Registry System: (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enol(1332523-77-9)

Safety Data

• Hazardous Substances Data: 1332523-77-9(Hazardous Substances Data)

Upstream product

• 73903-22-7 N-<2-(3,5-Dimethoxyphenyl)athyl>-trifluoracetamid 
• 1332523-76-8 3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-ynol 
• 1332523-75-7 1-iodo-4,6-dimethoxy-2-[2-(trifluoroacetylamino)ethyl]-benzene 

Downstream Products

• 1332523-71-3 ethenyl (Z)-3-{4,6-dimethoxy-2-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-enyl carbonate 

Relevant articles and documents

Enantioselective synthesis of 1-vinyltetrahydroisoquinolines via Pd-catalyzed intramolecular asymmetric allylic amination reactions

1-Vinyltetrahydroisoquinolines serve as versatile intermediates for the synthesis of a variety of naturally occurring isoquinoline alkaloids. 1-Vinyl-6,8-dimethoxytetrahydroisoquinoline 4 and 1-vinyl-5,6,7- trimethoxytetrahydroisoquinoline 6 with >90% ee by means of Pd-catalyzed intramolecular asymmetric allylic amination reactions, using MPN and BOP ligands, developed in our laboratory. The fine-tuning capability of the MPN and BOP ligands has played a significant role in the optimization of enantioselectivity. Interesting substituent effect as well as solvent effect on the product selectivity and enantioselectivity was observed. Plausible mechanisms are proposed, which can accommodate various findings, including the critical importance of the activation of the trifluoroamide moiety through its coordination to the Lewis acidic Pd2+ metal center.