1332525-53-7

Upstream product

• 1332525-41-3 1-(2-morpholinopyrimidin-4yloxy)-1H-benzo[d]-[1,2,3] triazole 
• 1332525-44-6 tert-butyl (S)-1-(methoxycarbonyl)-5-(1-(2-morpholinopyrimidin-N-yl)amino)pentylcarbamate 
• 55757-60-3 N-α-(tert-butoxycarbonyl)-L-lysine methyl ester 

Relevant academic research and scientific papers

Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts

Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.