1332531-41-5

Basic information

• Product Name: 2-propanone, 1-[3-bromo-1,2,5,6-tetrahydro-6-(2-propenyl)-
• Synonyms: 1-(6-allyl-3-bromo-1,2,5,6-tetrahydropyridin-2-yl)acetone hydrochloride;2-propanone, 1-[3-bromo-1,2,5,6-tetrahydro-6-(2-propenyl)-;1-(5-bromo-2-prop-2-enyl-1,2,3,6-tetrahydropyridin-6-yl)propan-2-one:hydrochloride
• CAS NO: 1332531-41-5
• Molecular Formula: C11H17BrClNO
• Molecular Weight: 294.61578
• Mol File: 1332531-41-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-propanone, 1-[3-bromo-1,2,5,6-tetrahydro-6-(2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propanone, 1-[3-bromo-1,2,5,6-tetrahydro-6-(2-propenyl)-(1332531-41-5)
• EPA Substance Registry System: 2-propanone, 1-[3-bromo-1,2,5,6-tetrahydro-6-(2-propenyl)-(1332531-41-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1332531-41-5(Hazardous Substances Data)

Relevant articles and documents

Preparation of α-acetonylpiperidines from α-allylated heterocycles by a bromocyclocarbamation reaction

2,6-Disubstituted (alkyl)(allyl)- and diallylpiperidines containing C=C bonds in different environments can be selectively transformed into α-acetonylpiperidines, including the alkaloid (±)-6-epipinidinone. The key step is the bromocyclocarbamation reaction of the N-Boc-protected α-allylheterocycle with N-bromosuccinimide. The bulky tert-butyl group on the piperidine ring can affect the diastereoselectivity of the cyclization by 1,5-asymmetric induction. The structure of one of the isolated diastereomers was established by X-ray single-crystal diffraction. The prepared bicyclic bromides were readily dehydrobrominated with tBuOK and the corresponding enols were hydrolyzed to α-acetonylpiperidine hydrochlorides. The method presented is convenient and simple to perform. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.