133263-76-0Relevant academic research and scientific papers
Remote and Selective C(sp2)-H Olefination for Sequential Regioselective Linkage of Phenanthrenes
Wei, Yi,Duan, Abing,Tang, Pan-Ting,Li, Jia-Wei,Peng, Rou-Ming,Zhou, Zheng-Xin,Luo, Xiao-Peng,Kurmoo, Mohamedally,Liu, Yue-Jin,Zeng, Ming-Hua
, p. 4129 - 4134 (2020)
Biphenylcarboxylic acid with two competing C(sp2)-H sites was designed for site selective C(sp2)-H functionalization by developing carboxylic acids assisted remote and selective olefination via 7-membered palladacycle. Mechanism investigation and DFT calculations reveal a kinetics-determined process, which could be utilized to explore a variety of remote site selectivity. The practicability of this method was highlighted by the precise construction of phenathrene under sequential site selectivity.
Synthesis of seven-membered lactones by regioselective and stereoselective iodolactonization of electron-deficient olefins
Ke, Zhuofeng,Li, Ming,Liu, Yue-Jin,Luo, Xiao-Peng,Shao, You-Xiang,Tang, Pan-Ting,Wang, Liang-Neng,Wei, Yi,Zeng, Ming-Hua,Zhang, Ni-Juan
, p. 6680 - 6683 (2020/07/03)
A regio- A nd stereoselective iodolactonization of internal electron-deficient olefinic acids has been reported, which provides a straightforward access to a series of multi-functionalized seven-membered lactones containing two consecutive chiral centers. The ester substituents on the olefins played a key role in achieving high regioselectivity. This result was proved through experiments and DFT calculations.
N-ACRYLOYLPIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PAF ANTAGONISTS
-
, (2008/06/13)
Compounds of formula (I): STR1 wherein R 1 and R 2 is each--R 5,--CH=CH--R 5 or--C C--R 5, wherein R. sup.5 is optionally substituted aryl or aromatic heterocyclic; R 3 is hydrogen, alkyl, cyano or--R 5 ; X is oxygen or sulfur; A is 1,4-piperazin-1, 4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R 4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecular with a compound containing the other part of the molecule.
