1332708-14-1 Usage
Description
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]is a complex organic molecule characterized by the presence of a pyrimidine ring and multiple functional groups. 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]features a 4-[(2-Methylpropyl)aMino] group, a N-(phenylMethyl) group, and a 2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl] group. Its structure suggests potential pharmaceutical or biological activity, particularly due to the inclusion of the piperazine ring, which is a common feature in many drugs. The exact function or application of this compound would be determined by its synthesis and the specific goals of the research or industry in which it is utilized.
Uses
Used in Pharmaceutical Industry:
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]is used as a potential pharmaceutical agent for its possible biological activity. The presence of the piperazine ring indicates that it may have applications in the development of new drugs, particularly if its synthesis can be tailored to target specific biological pathways or receptors.
Used in Research and Development:
In the field of chemical research and development, 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]serves as a subject for exploration into the synthesis of novel compounds with potential therapeutic effects. Its unique structure may offer insights into the design of new molecules with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1332708-14-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,2,7,0 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1332708-14:
(9*1)+(8*3)+(7*3)+(6*2)+(5*7)+(4*0)+(3*8)+(2*1)+(1*4)=131
131 % 10 = 1
So 1332708-14-1 is a valid CAS Registry Number.
1332708-14-1Relevant articles and documents
Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel
Ryckmans, Thomas,Aubdool, Aisah A.,Bodkin, Jennifer V.,Cox, Peter,Brain, Susan D.,Dupont, Thomas,Fairman, Emma,Hashizume, Yoshinobu,Ishii, Naoko,Kato, Teruhisa,Kitching, Linda,Newman, Julie,Omoto, Kiyoyuki,Rawson, David,Strover, Jade
, p. 4857 - 4859 (2011/09/16)
TrpA1 is an ion channel involved in nociceptive and inflammatory pain. It is implicated in the detection of chemical irritants through covalent binding to a cysteine-rich intracellular region of the protein. While performing an HTS of the Pfizer chemical collection, a class of pyrimidines emerged as a non-reactive, non-covalently binding family of agonists of the rat and human TrpA1 channel. Given the issues identified with the reference agonist Mustard Oil (MO) in screening, a new, non-covalently binding agonist was optimized and proved to be a superior agent to MO for screening purposes. Compound 16a (PF-4840154) is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse.
