1332726-37-0Relevant articles and documents
P2-P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis
Lampa, Anna,Ehrenberg, Angelica E.,Vema, Aparna,Kerblom, Eva,Lindeberg, Gunnar,Helena Danielson,Karlen, Anders,Sandstroem, Anja
, p. 4917 - 4927 (2011)
Macrocyclization is a commonly used strategy to preorganize HCV NS3 protease inhibitors in their bioactive conformation. Moreover, macrocyclization generally leads to greater stability and improved pharmacokinetic properties. In HCV NS3 protease inhibitor