1332758-16-3Relevant articles and documents
Total synthesis of pacidamycin D by Cu(I)-Catalyzed oxy enamide formation
Okamoto, Kazuya,Sakagami, Masahiro,Feng, Fei,Togame, Hiroko,Takemoto, Hiroshi,Ichikawa, Satoshi,Matsuda, Akira
, p. 5240 - 5243 (2011)
The first total synthesis of pacidamycin D, which is expected to be a good candidate as an antibacterial agent against P. aeruginosa, is described. The key elements of our approach feature an efficient and stereocontrolled construction of the Z-oxyvinyl iodide and copper-catalyzed crosscoupling with the tetrapeptide carboxamide.