1332827-93-6

Basic information

• Product Name: 2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide
• CAS NO: 1332827-93-6
• Molecular Weight: 231.218
• Mol File: 1332827-93-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide(1332827-93-6)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide(1332827-93-6)

Safety Data

• Hazardous Substances Data: 1332827-93-6(Hazardous Substances Data)

Upstream product

• 1307727-86-1 1-phenyl-N-(1-(o-tolyl)ethylidene)methanamine 
• 194024-39-0 N-benzyl-1-(o-tolyl)ethan-1-amine 
• 35106-87-7 1-o-tolylethanamine hydrochloride 
• 577-16-2 2-Methylacetophenone 

Relevant articles and documents

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.