1332849-07-6Relevant articles and documents
Synthesis of macrotetrolide α, a designed polynactin analog composed of bishomononactic acids
Takai, Kentaro,Hanadate, Tadaatsu,Abe, Masaki,Ono, Yukie,Yamada, Teiko,Kuwahara, Shigefumi,Kiyota, Hiromasa
, p. 7066 - 7072 (2011/10/05)
Macrotetrolide α (1), a designed polynactin analog composed of (+)- and (-)-bishomononactic acids, was synthesized. The monomeric acids were prepared using cis-selective iodoetherification and optical resolution of the corresponding O-acetylmandelates as the key steps. Esterification and macrolactonization of the monomers were performed by Corey-Mukaiyama-Gerlach method. Compound 1 showed no immunosuppressive activity contrary to other natural polynactin congeners.