1332865-99-2Relevant academic research and scientific papers
Lewis base assisted Bronsted base catalysis: Direct regioselective asymmetric vinylogous alkylation of allylic sulfones
Jiang, Lin,Lei, Qian,Huang, Xin,Cui, Hai-Lei,Zhou, Xue,Chen, Ying-Chun
supporting information; experimental part, p. 9489 - 9493 (2011/09/16)
A Lewis base assisted Brnsted base catalysis (LBABB) strategy is applied for direct asymmetric vinylogous alkylation of allylic sulfones with Morita-Baylis-Hillman (MBH) carbonates, in which a strong Brnsted base, tert-butoxy anion, generated in situ from a tertiary amine catalyst and MBH carbonate, is crucial in activating unstabilized nucleophiles. The γ-regioselective alkylation products were obtained with good to excellent enantiomeric excess values when catalyzed by a modified cinchona alkaloid. Copyright
