1332887-87-2

Upstream product

• 545-06-2 trichloroacetonitrile 
• 388631-81-0 (E)-3-(3,5-dimethyl-phenyl)-prop-2-en-1-ol 
• 5779-95-3 3,5-dimethylbenzaldehyde 
• 865484-89-5 (2E)-3-(3,5-dimethyl-phenyl)-acrylic acid ethyl ester 

Downstream Products

• 1332887-96-3 2,2,2-trichloro-N-[1-(3,5-dimethylphenyl)allyl]acetamide 
• 1270539-42-8 1-(3,5-dimethylphenyl)-prop-2-en-1-amine 
• 1213668-79-1 (R)-1-(3,5-dimethylphenyl)-prop-2-en-1-amine 
• 1213557-87-9 (S)-1-(3,5-dimethylphenyl)-prop-2-en-1-amine 
• 1332888-06-8 C₁₃H₁₇NO 

Relevant academic research and scientific papers

An efficient enzymatic approach to (S)-1-aryl-allylamines

A range of 1-aryl-allylamines were prepared in moderate to excellent enantioselectivity (ee 63.5%→99.9%) using lipase B from a Candida antarctica catalyzed resolution of racemic amines. This is the first time that CaLB has been used for the resolution of 1-aryl-allylamines. Racemic amines were prepared starting from aromatic aldehydes with a [3,3]-sigmatropic rearrangement of the acyclic imidates as the key step followed by trichloroacetamidate hydrolysis. Aldehydes were converted into acrylic esters using Knoevenagel reaction. After reduction, the corresponding alcohols were used for the preparation of trichloroacetimidates, which were then used in an Overman rearrangement.