1332941-39-5Relevant articles and documents
Copper(i)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core
Proietti Silvestri, Ilaria,Andemarian, Fikre,Khairallah, George N.,Wan Yap, Su,Quach, Tim,Tsegay, Sammi,Williams, Craig M.,O'Hair, Richard A. J.,Donnelly, Paul S.,Williams, Spencer J.
, p. 6082 - 6088 (2011)
Silver acetylides and organic azides react under copper(i) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core.