1332941-44-2Relevant academic research and scientific papers
Copper(i)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core
Proietti Silvestri, Ilaria,Andemarian, Fikre,Khairallah, George N.,Wan Yap, Su,Quach, Tim,Tsegay, Sammi,Williams, Craig M.,O'Hair, Richard A. J.,Donnelly, Paul S.,Williams, Spencer J.
experimental part, p. 6082 - 6088 (2011/10/08)
Silver acetylides and organic azides react under copper(i) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core.
