133300-54-6Relevant articles and documents
Synthesis of nitroxyalkylammonium nitrates
Romanova, L. B.,Ivanova, M. E.,Nesterenko, D. A.,Eremenko, L. T.
, p. 1207 - 1208 (1994)
A method for O-nitration of amino alohols with a non-detonating mixture of nitric acid with dichloromethane has been proposed.The target crystalline products were precipitated from the reaction mixture by acetic anhydride. - Key words: nitroxyalkylammonium nitrates; amino alcohols; O-nitration; concentration limits of detonation; explosion-proof process.
Nitroxide derivative of ROCK kinase inhibitor
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Paragraph 0475-0481, (2020/06/17)
The invention provides a small molecular compound of a NO donor. The small molecular compound is characterized in that the small molecular compound is a compound shown represented by structural formula I shown in the description, or a stereoisomer, a geometrical isomer, a tautomer, a racemate, a deuterated isotope derivative, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof; and in the formula I, ring A is a substituted or unsubstituted heteroaromatic ring, X is selected from (CH2)n, n is selected from 0, 1, 2 and 3, R is a substituent group of terminal -O-NO2, R is selected from hydrogen, a hydroxyl group, halogen, an amino group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group and a substituted or unsubstituted heteroalkyl group, and R and R are respectively and independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted naphthenic base or an amino protecting group, or R and R are connected to form a substituted or unsubstituted cyclic heteroalkyl group. The compound has a high-activity inhibition effect on ROCK kinase.
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors
Biava, Mariangela,Battilocchio, Claudio,Poce, Giovanna,Alfonso, Salvatore,Consalvi, Sara,Di Capua, Angela,Calderone, Vincenzo,Martelli, Alma,Testai, Lara,Sautebin, Lidia,Rossi, Antonietta,Ghelardini, Carla,Di Cesare Mannelli, Lorenzo,Giordani, Antonio,Persiani, Stefano,Colovic, Milena,Dovizio, Melania,Patrignani, Paola,Anzini, Maurizio
, p. 772 - 786 (2014/01/23)
We report herein the development, synthesis, physicochemical and pharmacological characterization of a novel class of pharmacodynamic hybrids that selectively inhibit cyclooxygenase-2 (COX-2) isoform and present suitable nitric oxide releasing properties.
