1333015-32-9

Basic information

• Product Name: 3-azido-3'-deoxythymidin-5'-yl (N-phenyl)phosphoramidate triethylammonium salt
• CAS NO: 1333015-32-9
• Molecular Weight: 523.529
• Mol File: 1333015-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-azido-3'-deoxythymidin-5'-yl (N-phenyl)phosphoramidate triethylammonium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 3-azido-3'-deoxythymidin-5'-yl (N-phenyl)phosphoramidate triethylammonium salt(1333015-32-9)
• EPA Substance Registry System: 3-azido-3'-deoxythymidin-5'-yl (N-phenyl)phosphoramidate triethylammonium salt(1333015-32-9)

Safety Data

• Hazardous Substances Data: 1333015-32-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 124930-59-2 3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester 
• 1333015-16-9 C₁₆H₁₉N₆O₅P 
• 121-44-8 triethylamine 

Relevant articles and documents

Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity

New synthetic protocol for the preparation of nucleoside 5′-(N-aryl)phosphoramidate monoesters 4 was developed. It consisted of a condensation of the corresponding nucleoside 5′-H-phosphonates with aromatic- or heteroaromatic amines promoted by diphenyl phosphorochloridate, followed by oxidation of the produced H-phosphonamidates with iodine/water. 5′-(N-Aryl)phosphoramidate monoesters derived from 3′-azido- 3′-deoxythymidine (AZT) or 2′,3′-dideoxyuridine (ddU) nucleosides and various aromatic and heteroaromatic amines were evaluated as potential anti-HIV drugs. It was found that these compounds act most likely as pronucleotides and that some of them have therapeutic indices superior to those of the reference AZT.