1333077-66-9

Upstream product

• 1333077-63-6 2-(allyloxy)-4-iodopyrimidine 
• 1179522-58-7 (2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid 
• 1333077-64-7 tert-butyl (2R, 4S)-2-(tert-butyl)-4-carbamoyl-4-methyl-4-methyloxazolidine-3-carboxylate 
• 1333077-65-8 N-(2-(allyloxy)pyrimidin-4-yl)-4-iodobenzamide 
• 1333077-62-5 2-(allyloxy)-4-bromopyrimidine 
• 145625-08-7 (2R,4S)-2-tert-butyloxazolidinone-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 

Downstream Products

• 1333077-71-6 (S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride 

Relevant academic research and scientific papers

Synthesis of cytimidine through a one-pot copper-mediated amidation cascade

A concise synthesis of cytimidine was developed utilizing tandem Cu-mediated N-aryl amidations followed by global deprotection. This sequence exploits a regioselective coupling of an iodobenzamide with a halopyrimidine that allows the union of three fragments in a single synthetic manipulation and will permit the efficient and rapid diversification of the cytimidine core.